July 23, 2018
BioGenetic Laboratories HCG Activator Review
BioGenetic Laboratories claims this product instantly reduces the desire to snack by 100% and flushes out up to 7 pounds of fat in one week.
In order to examine these claims, we need to look closer at the HCG diet, and then look at what HCG Activator does to support it.
The HCG Diet
According to BioGenetic Laboratories, the HCG diet brings new hope to dieters through its influence on HCG, or Human Chorionic Gonadotropin, a hormone released during pregnancy.
This hormone supposedly triggers the hypothalamus to release extra fat, so when you are on an extremely low calorie diet, the HCG “helps make up the difference in the calories it needs to function by using your stored fat as food.”
The HCG diet was first proposed in in the 1950s by Dr. Albert T. Simeons, who supported the idea of HCG injections to allow dieters to eat just 500 calories a day. Although this diet was denounced by the FDA and the FTC, it was recently reintroduced by infomercial maker Kevin Trudeau. 
The HCG diet plan included with HCG Activator is purportedly similar to the plan proposed by Simeons. Unfortunately, there is little evidence this diet actually works.
One meta-analysis assessed 24 papers and trials on HCG’s effects, and experts determined most studies were of poor quality. Among the 12 higher quality studies, only 1 found HCG effective for weight loss. 
HCG Activator Ingredients
The product description says HCG Activator is a “natural alternative to HCG administration,” so presumably the ingredients affect HCG levels.
Human Chorionic Gonadotropin Glycopeptide Stimulating Complex (758 mg)
L-Arginine. This amino acid is necessary for protein building and is converted into nitric oxide, which improves blood flow. Although arginine may stimulate release of growth hormone and other substances, there is no proof it stimulates HCG release. 
L-Ornithine. Although some use this amino acid to improve athletic performance, its effectiveness is unknown.  Treatment of female rats with HCG increased ornithine activity, but it’s unclear whether increased ornithine also increases HCG. 
Huperzine A. Huperzine A may benefit memory loss and dementia due to its ability to increase acetylcholine levels, which communicate with the brain and muscles.  Its exact connection to HCG levels is unknown.
N-Acetyl-L-Carnitine. N-acetyl-l-carnitine is a more absorbable carnitine form. Carnitine is an amino acid crucial to heart and brain function as well as muscle movement. Although carnitine increased fat metabolism and improved female reproductive cell development, its ability to increase HCG is unclear. 
Green Tea Leaf Extract. Green tea supports weight loss through thermogenesis and fat oxidation.  But, this is not connected to HCG.
Saffrolite Saffron Extract. According to studies, saffron extract decreases body weight by reducing snacking. Consequently, experts believe it may support a weight loss program. 
Black Cohosh. Black cohosh acts similarly to estrogen. It may induce labor but is not directly connected to HCG. 
It’s unclear whether these ingredients are supposed to increase HCG, imitate HCG, or perform a different function altogether. The company may have simply used the name of a popular fad diet to promote this supplement.
Taking HCG Activator
Take one serving (2 capsules) twice daily with a glass of water, preferably on an empty stomach. The first serving should be consumed before breakfast and the second six hours later.
The product should accompany the free diet plan enclosed, which is based on Simeons’ HCG diet plan.
You are more likely to lose weight from the low-calorie intake than from HCG Activator’s ingredients. Many ingredients lack clinical evidence to support product claims.
However, taking in so few calories is also detrimental to health, leading to side effects like gallstone formation, irregular heartbeat, and electrolyte imbalance. 
Purchasing HCG Activator
HCG Activator is available at GNC.com for $79.99 and at Amazon.com for $52.99. This is highly expensive for a product that does not contain HCG nor is proven to raise HCG. The company, no doubt, is relying on HCG product demand to inflate the price.
Should You Buy HCG Activator?
Scientific evidence does not show HCG Activator’s ingredients affect HCG levels. However, some ingredients are clinically proven fat burners, and many consumers experienced positive results while using HCG Activator.
But, the HCG diet that accompanies HCG Activator is potentially dangerous and not proven to work.
 Stephen Barrett, MD. “HCG Worthless as Weight-Loss Aid.” Diet Scam Watch. Available from: http://www.dietscam.org/reports/hcg.shtml
 GK Lijesen et al. “The effect of human chorionic gonadotropin (HCG) in the treatment of obesity by means of the Simeons therapy: a criteria-based meta-analysis.” Br J Clin Pharmacol. 1995; 40 (3): 237-243. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365103/
 “L-Arginine.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-875-arginine.aspx?activeIngredientId=875&activeIngredientName=arginine&source=1
 “Ornithine.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-200-ORNITHINE.aspx?activeIngredientId=200&activeIngredientName=ORNITHINE
 G.J. Sertich, L. Persson, A.E. Pegg. “Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin.” American Journal of Physiology. Cell Physiology. 1987; 253 (5): C687-C692. Available from: http://ajpcell.physiology.org/content/253/5/C687.short
 “Huperzine A.” WebMD.com. Available from: http://www.webmd.com/vitamins-supplements/ingredientmono-764-huperzine.aspx?activeIngredientId=764&activeIngredientName=huperzine&source=1
 Dunning KR et al. “Increased beta-oxidation and improved oocyte developmental competence in response to l-carnitine during ovarian in vitro follicle development in mice.” Biol Reprod. 2011; 85 (3): 548-55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21613630
 Margriet S. Westerterp-Plantenga, Manuela P.G.M. Lejeune, Eva M.R. Kovacs. “Body Weight Loss and Weight Maintenance in Relation to Habitual Caffeine Intake and Green Tea Supplementation.” Obesity Research. 2005; 13 (7): 1195-1204. Available from: http://onlinelibrary.wiley.com/doi/10.1038/oby.2005.142/full
 Gout B, Bourges C, Paineau-Dubreuil S. “Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.” Nutr Res. 2010; 30 (5): 305-13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20579522
 Rachel Emma Westfall. “Herbal medicine in pregnancy and childbirth.” Advances in Therapy. 2001; 18 (1): 47-55. Available from: http://link.springer.com/article/10.1007/BF02850250#page-1
 Jennifer K. Nelson. “Does the HCG diet work – and is it safe?” MayoClinic.com. Available from: http://www.mayoclinic.com/health/hcg-diet/an02091