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Kimberly Tenner
November 28, 2019

Calotren Review


Created and distributed by Top of the World Distributors, Calotren is a popular diet pill designed to do everything from building lean muscle to improving joint mobility to promoting sleep and to adding elasticity and strength to skin.

According to manufacturers, Calotren contains unique collagen protein which “promotes inch and weight loss.” Futhermore, Calotren’s ingredients supposedly help you lose weight in your sleep – without the need for excessive dieting or exercise.

Yet can Calotren’s ingredients live up to these over-the-top claims? I can’t help but be a little skeptical, so I did a little digging to find out the truth. . .

Inside the Bottle

Calotren is available in two forms: liquid and capsule. Both formulas feature collagen hydrolysate, but the liquid calotren contains additional preservatives and flavors. Manufacturers fail to specify how much of each ingredient is used, but the FAQ page does give us a short ingredient list.

Here’s a quick breakdown of what you’re going to find . . .

Collagen Hydrolysate. Also known as hydrolyzed collagen, this protein is produced from collagen found in the bones, skin, and connective tissue of animals. According to manufacturers, this particular form of collagen hydrolysate was extracted from beef. “The beef is safe and has no health risks for consumers.” Calotren contains 3 grams of protein per serving.

Hydrolyzed collagen contains 8 out of the 9 essential amino acids, including glycine and arginine which act as precursors for creatine production. It assists in rebuilding muscles and joints.
Clinical studies suggest ingested collagen could be used as a “therapeutic agent . . . In the treatment of osteoarthritis and osteoporosis.”[1]

While many believe collagen hydrolysate is crucial for restoring lean muscle mass, there is not enough clinical information to validate claims for weight loss.

Aloe Vera. Although topical aloe vera is commonly used to treat skin conditions, oral aloe vera contains chemicals that work as laxatives. Experts recommend 100-200 mg of aloe for relieving constipation, but we do not know how much is used in Calotren. Furthermore, laxatives such as aloe vera only reduce water weight not fat, so this ingredient does little to trim the extra pounds.

Vegetable Glycerin. Also known as glycerol, vegetable glycerin attracts water into the gut, softening stools to relieve constipation. It helps replace water lost during diarrhea and vomiting, and can prevent dehydration. Like aloe vera, glycerin may be used as a laxative but there is little to validate any weight loss claims.

Is There a Difference Between the Liquid and the Capsules?

Aside from the additional preservatives and flavors, I can’t find a difference in ingredients between the two formulas. The price for both products is the same, though you’ll have to specify which package you want when you order from

On the other hand, I don’t know ingredient concentrations for either product, so I don’t know if one formula is more effective than the other.

Safety Concerns and Side Effects

Despite manufacturer’s claims that Calotren is side effect free, it might not be as safe as advertisements would leave you to believe.

According to Leslie Brooks at, “If you are at all sensitive to taking pills, don’t do this! I followed the instructions, waited the 3 hours after eating before taking it, and then barely slept all night. It says “no stimulants” but something kept me awake and feeling sick all night.”

Calotren contains hydrolyzed collagen, which is made from animal by-products. It is possible that consuming hydrolyzed collagen increases the risk of contracting transmissible spongiform encephalopathy, a disease that affects the brain and central nervous system.

According to the FDA, the TSE (transmissible spongiform encephalopathy) Advisory Committee closely monitors the potential risk of transmitting the disease through bovine sources, so this side effect is rare[2].

Aloe vera can cause side effects such as stomach pain and cramps, and long-term use of aloe in large amounts might cause diarrhea, kidney problems, low potassium and muscle weakness. Exercise caution before using Calotren as it contains unknown amounts of aloe vera.

Vegetable glycerin, although safe for most adults when applied topically, may cause headaches, dizziness, bloating, nausea, vomiting, thirst, and diarrhea when ingested.

Calotren does not contain any drugs, caffeine, or other stimulants, so supposedly it won’t interact negatively with medication. However, you’ll want to consult your doctor before using Calotren, just in case.

What About the Taste?

Liquid Calotren is flavored with natural and artificial raspberry flavors, but that doesn’t mean it appeals to everyone who drinks it.

Manufacturers state if you are sensitive to the taste, mix liquid Calotren with a glass of water or water with lemon.

How to Use Calotren

Manufacturers provide strict instructions on how to take Calotren:

“Do not eat or drink anything other than water or water with lemon for at least three hours prior to taking Calotren. Take four Calotren capsules or 1 tbsp. of Calotren liquid with a glass of water at bedtime.”

Supposedly if dieters use Calotren as directed, they should see results within 4-6 weeks of use. However, individual results will vary.

Missed Dosage. If you miss an evening dose, you can take Calotren in the morning before you eat or drink anything. Take the recommended dosage (1 tbsp. or 4 capsules), drink a glass of water, and wait 30 minutes before you eat or drink anything else. You may then resume your regular dosage the same night.

Product Pricing

Both the liquid and the capsules are available for the same price at

• 1 Month Supply: $69.95
• 2 Month Supply: $104.93 – buy 1 get 1 half off
• 5 Month Supply: $189.00 – buy 3 get 2 free

However, you can find Calotren at and for $55 a bottle (with free shipping).

More About the Manufacturers

Calotren was created by Top of the World Distributors in February 2001. The company is based in Tennessee and has an amazing record at the Better Business Bureau.

According the BBB, Top of the World Distributors scored an A+ rating on an A+ to F scale. It meets BBB accreditation standards, and in the last 3 years, only 1 complaint has been filed against the company. Top of the World Distributors responded quickly and promptly to the complaint.

Compared to other diet pill manufacturers, Top of the World Distributors seems to offer reliable customer service.

Pick it or Pitch it?

I’m not entirely convinced Calotren can live up to all its claims. There is little evidence to suggest its key ingredients are effective for weight loss. Furthermore, its high price and poor consumer reviews make me skeptical that Calotren is a worthy investment.


[1] Moskowitz, Roland. “Role of collagen hydrolysate in bone and joint disease.” Seminars in Arhtritis & Rheumatism. 2000. 30:87-99. Available from:

[2] “The Sourcing and Processing of Gelatin to Reduce the Potential Risk Posed by Bovine Spongiform Encephalopathy (BSE) in FDA-Regulated Products for Human Use.” US Food and Drug Administration. Sep. 1997. Available from:

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Dennis Kreifels Says:

I have been on calotren for two months now and I have not lost one pound nor one inch in the waistline. I am not sure how long it takes before you start seeing results. Will continue to take it just to see if it works or not. No problems with taking it so far.

November 17, 2015 at 1:35 pm

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