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Kimberly Tenner
November 29, 2019

Nature’s Best Isopure Original Review

Nature’s Best Isopure Original

Nature’s Best Isopure Original is “replacing meals with taste,” according to the official website. But Isopure Original is more than a tasty protein powder. It also contains various nutrients that the body needs each day.

So, is Isopure Original a meal replacement shake worth trying? Let’s see what we can learn about the formula and the flavors — because both can make or break a product.

The Supplement Facts

Isopure Original comes as a bucket with powder or a box of individual packets. One serving is 3 scoopfuls (86-90 g) or 1 packet (87 g). These quantities are included in each serving — varying slightly from flavor to flavor:

• 300 calories
• 0 g fat
• 10 mg cholesterol
• 320 mg sodium
• 750 mg potassium
• 25 g carbohydrates
• 1 g sugar
• 50 g protein

In addition, Isopure Original contains 24 essential vitamins and minerals such as vitamin A, iron, folate, magnesium, and zinc. Each serving contains 50% Daily Value of all the nutrients, except four: 60% DV calcium, 6% DV iron, 100% DV chromium, and 20% DV chloride.

What Are the Flavors?

There are 3 flavors to choose from when you buy the bucket:

• Dutch Chocolate
• Strawberries & Cream
• Vanilla

The packets offer a few more options:

• Chocolate Peanut Butter Swirl
• Orange-Creamsicle
• Strawberries & Cream
• Vanilla
• Variety

Users like chocolate peanut butter swirl best and vanilla is a close second.

The Ingredients

The vitamins and minerals in Isopure Original are what make it a meal replacement shake rather than a protein shake. Essential nutrients aside for a moment; Isopure Original only has a couple remaining ingredients:

Whey Protein Isolate – This is the purest protein type available because it’s highly filtered. The filtering removes almost all lactose and cholesterol, leaving pure protein. In fact, whey protein isolate is 90% protein by weight. The downside is it has fewer nutrients than other types. The upside is it’s easier to digest and less likely to cause allergic reactions.

Research shows whey protein isolate enhances muscle repair, increases strength, reduces body fat, and stimulates lean muscle growth.[1][2] It also enhances muscle protein synthesis better than micellar casein.[3]

Maltodextrin – Commonly used as a sweetener, maltodextrin is an easily-digestible carbohydrate. Because it converts into sugar so easily, it’s a fast source of energy. Maltodextrin must be used quickly or increased fat storage, bloating, and digestive issues may result.

And then of course, Nature’s Best Isopure Original has a few natural and artificial flavoring ingredients.

How Much Should You Take?

Combine 3 level scoops or 1 packet with 12 oz. water. If you want a creamier shake with more calories, combine Isopure Original with milk.

It mixes best if you add the powder first and then the fluid. Isopure Original mixes well in a shaker cup or blender. If those aren’t available, stirring the mixture with a spoon should do the trick.

Take Isopure Original in place of a meal or snack. For best results, take it before or soon after a workout.

Isopure Original is safe, but should be kept away from children. Iron overdose may cause fatal poisoning in young children.

My only concern with the formula is that there is 50 g protein in each serving. This is a huge dosage, which may be difficult to digest and absorb completely. Any undigested protein will get flushed from the body and wasted, but first it may cause bloating and digestive issues.

Where to Buy Nature’s Best Isopure Original

Although provides information about its product, it doesn’t sell Isopure Original. The site does provide a list with retailers, though. I compared several sites and found the best prices here:
• $54.69 per box
• 4.57 lbs. – 20 servings
• $86.93 per box
• 8.8 lbs. – 46 servings (Best Deal)
• $84.99 per box
• 8.8 lbs. – 46 servings
• $41.99 per box
• 4.57 lbs. – 20 servings


Nature’s Best Isopure Original is a great meal replacement shake. It provides many important nutrients in good dosages. So, you can substitute it for a meal without worrying about getting adequate nutrition.

Whey protein isolate is a high-quality ingredient with many proven benefits. The only downside is Isopure Original may provide more than users can handle in one sitting. Besides going to waste, the extra protein may cause side effects.

Overall, I think Nature’s Best Isopure Original is worth buying. But you may want to look around for a more affordable product before you buy this one.


[1] Cribb, PJ, AD Williams, et al. “The effect of whey isolate and resistance training on strength, body composition, and plasma glutamine.” International Journal of Sport Nutrition and Exercise Metabolism. 2006.16 (5): 494-509.

[2] Cooke, MB, E Rybalka, et al. “Whey protein isolate attenuates strength decline after eccentrically-induced muscle damage in healthy individuals.” Journal of the International Society of Sports Nutrition. 7.30 (2010).

[3] Burd, NA, Y Yang, et al. “Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men.” British Journal of Nutrition. 108.6 (2012): 958-62.

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