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Kimberly Tenner
November 28, 2019

Zyatonix Review


Created by Superbalife International LL, Zyatonix promises to eliminate fat more effectively than liposuction.

Zyatonix is said to be the only diet pill in the world to use apoptosis technology. Through the use of “quality compounds and engineering,” Zyatonix supposedly triggers fat cell death and increases caloric expenditure without the need for surgery or excessive exercise.

Sounds a little too good to be true, doesn’t it?

While I love a unique weight loss approach, I can’t help but wonder if Zyatonix is more hype than fact. I decided to do a little digging to find out the truth. . .

Click here to buy Zyatonix for $39.95.

What is Apoptosis?

Apoptosis is a type of cell death in which the cell utilizes its own machinery to kill itself. In a sense, it’s cell suicide. When a cell is compelled to commit suicide, proteins called caspases are activated. These proteins destroy the cell’s nucleus, causing it to shrink and send out additional distress signals. These signals are then answered by macrophages, your body’s personal “vacuum cleaners.” They clean away the shrunken cells, leaving no trace.

With this in mind, I have to admit, Zyatonix puts out an impressive mix of science and advertising. Zyatonix claims to work alongside this natural process, stating the following:

“You are born with a certain number of fat cells. When you diet and lose weight your fat cells shrink in size. When you gain the weight back the fat cells swell and increase in size. The number of fat cells never changes – just their size does.”

This is a fact.

However, Zyatonix pushes the boundary of fact and fiction by proclaiming, “Liposuction is so popular because it removes fat cells from your body never to return – but now Zyatonix actually kills fat cells without surgery – never to return!”

But can Zyatonix really achieve this result through all natural ingredients?

I’m not so sure. . .

Do the Ingredients Work?

According to the Zyatonix FAQ page:

“Zyatonix is an all-natural product and contains no synthetic drugs or chemicals. The key is Apopadex™, our proprietary complex of 5 compounds centered around Acacia Rigidula extract. Zyatonix’s other innovative compounds include Methylsynephrine, Phenylethylamine HCL, Cassis Nomame Extract, Theobromine, Yohimbe and EGCG.”

While this sounds very nice at first, it’s not entirely helpful. From the website, it’s impossible to tell whether these ingredients are in clinically proven concentrations or if they safe to use.
Consequently, I had to search elsewhere in order to find a more thorough ingredient list. What I found surprised me a little. Instead of 1 proprietary blend containing 6 ingredients, I found 2 proprietary blends with a long list of stimulants and appetite suppressors.

Apopadex – 280 mg
• Hoodia Gordonii – an unproven appetite suppressant supposedly used by African bushmen
• Citrus Aurantium – a “safe” alternative to ephedra that stimulates energy levels and metabolism
• Cassia Nomame – a lipase inhibitor which blocks dietary fat absorption
• 6,7 Dihydroxy Bergomottin – a grapefruit juice compound believed to affect metabolism
• Yohimbe extract – an African aphrodisiac that stimulates beta receptors to trigger fat loss
• Naringen – a citrus bioflavonoid that improves calcium absorption
• Commiphora Mukul – a thyroid stimulant believed to improve metabolism
• DMAE Bitartrate – a precursor to acetylcholine, a mood enhancing chemical in the brain
• Philocarpus Jaborandi – an herb that stimulates saliva and sweat production
• L-5-Hydroxy Tryptophan – a precursor to serotonin that may improve mood and reduce appetite
• 5- Methyoxy Tryptamine – a precursor to the hormone melatonin

Apopadex II – 200 mg
• Green Tea – a caffeine source rich in antioxidants that may increase energy and eliminate toxins
• Acacia Rigidula – a mild amphetamine that may increase energy levels
• Leptin – a fat regulating protein
• Theobroma Cocoa – a mood enhancing compound that eliminates toxins and lowers blood pressure
• Phenylethylamine HCL – an mood-enhancing, energy-boosting chemical found in chocolate

Caffeine Anhydrous – 75 mg
I’m not entirely sure where this ingredient falls in between the two blends, but it’s probably the most effective weight loss ingredient in Zyatonix. It stimulates the central nervous system to increase energy levels and decrease appetite. Unfortunately, 75 mg is barely enough to improve mental alertness. Most experts recommend taking 200-300 mg twice (or even three times) daily to promote weight loss.

Considering the fact that the 2 blends are divided among so many ingredients, I can assume that the concentrations are too low to be effective for weight loss, let alone trigger Apoptosis.

Furthermore, Zyatonix fails to provide clinical proof to validate its over-the-top Apoptosis claims. Even if one or two of the ingredients could achieve fat cell apoptosis, using the method for weight loss is absurd.

According to Elissa Lowe, former research associated with the Universe of California at Davis, “Even if they had an “effective” ingredient, let’s face it, lots of things can trigger apoptosis on a cell culture sitting in a dish. Whether they do so when ingested orally in a non-toxic dose is an entirely different matter, and one that would need to be demonstrated by genuine clinical studies.

“And…to push the “best case scenario” even further, a truly effective systemic agent capable of triggering fat cell death would not discriminate between “unnecessary” fat cells in a woman’s thighs…and equally unnecessary (from a body’s perspective) fat cells in a woman’s breasts. If the stuff really worked, female users would require breast implants.”

Are the Ingredients Safe?

While the formula isn’t aggressive enough to kill fat cells, Zyatonix should be approached with caution. While 500 mg servings might not seem like a lot, most of the ingredients in Zyatonix are stimulants.

Caffeine, citrus aurantium, and yohimbe are notorious for causing headaches, dizziness, nausea, vomiting, vertigo, jitters, rapid heartbeat, etc.

Liz at explains her experience with Zyatonix, “I feel like crap on this pill. They tell you you will feel warm and great but I felt like puking all morning and I am snapping at everyone. Instead of upping my mood, Zyatonix is making me very irritated and cranky. I absolutely hate the way this pill makes me feel and it’s only my 2nd day using it.”

Recommended Usage

According to the FAQ page, Zyatonix should be taken twice daily, preferably 1 hour before breakfast and 1 hour before lunch.

However, you may need to cut that dosage in half if you’re sensitive to stimulants. Try a single pill for the first few days to allow your body to adjust.

With so many stimulants in the formula, I suggest you avoid taking Zyatonix within 5 to 6 hours of bedtime.

While does not give additional guidelines for the product, I know that the best, most reliable results come from eating right and exercising frequently.

Is Zyatonix Expensive?

Zyatonix falls in the middle of the pricing scale. Although more expensive than generic products, it’s more affordable than diet pills that use the same ingredients.

If you order from, Zyatonix sells for $59.95. However, if you go through the manufacturers, Zyatonix is much cheaper

• 1 Bottle: $39.95
• 2 Bottle: $79.9 – receive 1 free bottle
• 3 Bottle: $149.95 – receive 3 free bottles

Zyatonix is backed with a 60-day “iron-clad” money-back guarantee. Supposedly it’s the “strongest guarantee in the history of the Weight loss business. . .No one offers this kind of guarantee- they can’t.”

And apparently, Zyatonix can’t either.

According to the Better Business Bureau, Zyatonix manufacturers Superbalife LLC have received countless complaints regarding refunds and credit card charges.

“Complainants allege unauthorized credit or debit card charges, false advertising, failure to honor their money back guarantee, and inability to obtain refunds. . . .Some complainants allege after returning products for refunds, the company issues only partial refunds. Others complain that although they are promised refunds, the company fails to send them. The company responds to some complaints by agreeing to issue full or partial refunds, disputing allegations, or offering explanations or clarification of their policies, terms and conditions.”

What Happened to Zyatrim?

Zyatonix may be copyrighted in 2012, but don’t mistake it for a new product. It’s actually a rebranded version of a discontinued product known as Zyatrim.

Since it was discontinued, there is little reliable information on the original formula. With the exception of a few sites selling Zyatrim (now Zyatonix) products, the most reliable information sources come from sites complaining about Zyatrim being a scam.

According to one headline, “Zyatrim, superbalife international Diet pill Co. refuses refund on phone order.”

Due to the negative publicity, I can see why Zyatrim had the name changed. By starting over with a clean slate, Zyatonix can attract new customers unfamiliar with the history while still maintaining the few loyal customers who actually lost weight.

Furthermore, it gives the manufacturers the chance to start over and rebuild their reputation by providing prompt and valuable customer support.

Judging from the BBB consumer reviews, however, it looks like the only thing Zyatonix changed was the name.

Final Thoughts

The ingredients in Zyatonix are effective. There are several consumer reviews reporting that Zyatonix promoted weight loss when no other diet pill could.

On the other hand, the undisclosed ingredient concentrations, false claims, high risk of negative side effects, and poor manufacturer reputation earn Zyatonix two thumbs down.

I suggest consumers stay away from Zyatonix and pick a more reliable supplement to promote weight loss. Though Zyatonix may work for you, I have no doubt that you can find a more affordable supplement that offers even better results.

Zyatonix Customer Reviews

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M. Black Says:

It really doesn’t suppress appetite. I tried to get my money back but I ended up having to contact my credit card company. I have tried a couple of diet pills in my day and this is by far the worst

December 18, 2010 at 8:08 pm

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